For individuals struggling with opioid or alcohol addiction, recovery can feel overwhelming—especially after multiple failed attempts at abstinence-only approaches. That’s where Medication-Assisted Treatment (MAT) offers new hope. MAT doesn’t just help you stop using—it helps you heal, function, and rebuild your life.
At MD M.A.T.T., a leading Medication-Assisted Treatment Center in Maryland, we use FDA-approved medications in combination with therapy and medical support to create powerful, sustainable recovery plans. But what medications are used in MAT—and how do they actually work?
In this article, we break down the key medications used in MAT, how they interact with the brain, and how our team at MD M.A.T.T. helps patients safely and effectively reclaim their lives.
What Is Medication-Assisted Treatment (MAT)?
MAT is an evidence-based treatment model that combines behavioral therapy and counseling with medications that:
- Reduce withdrawal symptoms
- Control cravings
- Block the euphoric effects of drugs or alcohol
- Support long-term brain healing and emotional stability
MAT is used to treat:
- Opioid Use Disorder (OUD)
- Alcohol Use Disorder (AUD)
It is endorsed by the National Institutes of Health (NIH), CDC, and Substance Abuse and Mental Health Services Administration (SAMHSA) as a gold standard of care.
MAT in Context: The Science and Impact
The National Institute on Drug Abuse (NIDA) reports that MAT:
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Reduces the risk of fatal opioid overdose by over 50%
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Improves patient retention in treatment
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Supports long-term sobriety and social reintegration
Despite this, only 1 in 4 people with opioid use disorder receives MAT, largely due to stigma and misinformation. At MD M.A.T.T., our mission is to change that narrative—one life at a time.
Key Medications Used in MAT and How They Work
Here’s a closer look at the most common medications we use at MD M.A.T.T., how they work, and who they help.
1. Suboxone (Buprenorphine + Naloxone)
Used for: Opioid Use Disorder
Administered as: Daily oral film or tablet
Suboxone is the most widely used medication for opioid addiction in outpatient settings. It combines two powerful agents:
- Buprenorphine is a partial opioid agonist, which means it binds to opioid receptors in the brain but doesn’t fully activate them. This reduces cravings and withdrawal symptoms without producing the intense euphoria of opioids like heroin or fentanyl.
- Naloxone is an opioid antagonist that prevents misuse. If someone attempts to inject Suboxone to get high, naloxone will trigger withdrawal symptoms, acting as a built-in deterrent.
Why it’s effective:
Suboxone helps individuals stabilize quickly, often within the first few days of induction. It allows for normal functioning, meaning patients can return to work, school, or parenting while staying sober.
MD M.A.T.T. is a trusted Suboxone Treatment Clinic in Maryland, offering safe initiation, ongoing monitoring, and support throughout Suboxone treatment.
2. Methadone
Used for: Opioid Use Disorder
Administered as: Daily liquid at specialized clinics
Methadone is a full opioid agonist, meaning it fully activates opioid receptors but at a controlled, stable dose. This makes it highly effective for individuals with long-term or severe opioid addiction who may not stabilize on Suboxone alone.
Why it’s effective:
Methadone has a long half-life, preventing the highs and crashes of short-acting opioids. However, it must be dispensed at a certified clinic due to its potential for misuse, which is why MD M.A.T.T. refers methadone candidates to approved partners.
3. Naltrexone (Vivitrol)
Used for: Opioid Use Disorder and Alcohol Use Disorder
Administered as: Monthly injection (Vivitrol) or daily oral tablet
Naltrexone is a pure opioid antagonist, meaning it blocks opioid receptors in the brain. It doesn’t reduce cravings directly but prevents any opioid from producing a high.
It’s also used for alcohol use disorder by reducing the reinforcing effects of alcohol, helping individuals drink less or stop altogether.
Why it’s effective:
Naltrexone is ideal for individuals who:
- Have already detoxed from opioids or alcohol
- Want a non-addictive MAT option
- Prefer once-a-month dosing (Vivitrol)
At MD M.A.T.T., we offer naltrexone as part of both alcohol and opioid recovery plans.
4. Acamprosate (Campral)
Used for: Alcohol Use Disorder
Administered as: Oral tablet taken 3x daily
Acamprosate works by restoring balance in the brain’s glutamate system, which is disrupted by long-term alcohol use. It helps reduce post-acute withdrawal symptoms such as:
- Insomnia
- Anxiety
- Restlessness
- Emotional instability
Why it’s effective:
Acamprosate does not produce a high and works best when paired with therapy and peer support. It’s often used for individuals with a history of chronic alcohol dependence who are committed to abstinence.
5. Disulfiram (Antabuse)
Used for: Alcohol Use Disorder
Administered as: Daily oral tablet
Disulfiram doesn’t reduce cravings—it acts as a deterrent. If someone drinks alcohol while on disulfiram, they will experience:
- Nausea
- Headache
- Chest pain
- Vomiting
Why it’s effective:
Disulfiram is most useful for individuals with high motivation, especially when paired with family accountability or structured support.
How We Personalize MAT at MD M.A.T.T.
Not every medication is right for every person. At MD M.A.T.T., we provide customized treatment planning that includes:
- Medical and psychiatric evaluations
- Substance use history and severity
- Risk of withdrawal or overdose
- Recovery goals and lifestyle needs
- Co-occurring mental health conditions
Each plan is reviewed regularly, and medications are adjusted based on progress and comfort.
Medications + Therapy = Real Recovery
While medications address physical dependence and brain chemistry, therapy targets the emotional, psychological, and behavioral patterns that fuel addiction.
At MD M.A.T.T., every MAT plan includes:
- Cognitive Behavioral Therapy (CBT)
- Motivational Interviewing (MI)
- Trauma-informed care
- Relapse prevention planning
- Peer support and case management
This integrated model helps you build skills for long-term stability, self-worth, and connection.
Addressing Safety and Myths About MAT Medications
Myth: MAT just replaces one drug with another.
Fact: These medications do not produce a high when taken as prescribed. They stabilize, not sedate.
Myth: You’re not “really sober” if you’re on medication.
Fact: Recovery isn’t about punishment—it’s about restoring function and quality of life.
Myth: MAT is a short-term fix.
Fact: Many benefit from long-term or lifetime use, just like with antidepressants or insulin.
Why MD M.A.T.T. Is a Trusted Leader in MAT in Maryland
As a premier provider of Addiction Treatment Services in Maryland, MD M.A.T.T. offers:
- Compassionate, stigma-free care
- Same-day appointments and telehealth options
- Certified providers in Suboxone and other MAT protocols
- A full-service Suboxone Treatment Clinic Maryland residents trust
- A proven track record of long-term recovery outcomes
Whether you’re beginning your journey or seeking relapse prevention, our team is here to help you succeed.
Ready to Begin MAT? Contact MD M.A.T.T. Today
Understanding your options is the first step toward recovery. Whether you’re struggling with opioids or alcohol, MAT could be the turning point you’ve been waiting for.
You don’t have to fight addiction alone. At MD M.A.T.T., we’ll help you choose the right MAT medication, provide the therapy you need, and support you through every phase of recovery. Call 410.364.8194 to schedule your confidential consultation and find out which MAT option is right for you. Your recovery deserves medical care, emotional support, and a team who believes in your future.
Frequently Asked Questions (FAQ)
What is the most commonly used medication in MAT for opioid addiction?
The most common medication is Suboxone (buprenorphine/naloxone). It reduces cravings and withdrawal symptoms without producing a euphoric high. At MD M.A.T.T., we provide comprehensive care through our trusted Suboxone Treatment Clinic in Maryland, including safe induction, ongoing monitoring, and tapering plans.
How is MAT different from just taking medication?
MAT isn’t just about medication—it’s a full recovery model. At MD M.A.T.T., every MAT plan includes behavioral therapy, medical supervision, and relapse prevention to treat the whole person, not just the symptoms of addiction.
Is Suboxone safe to use long term?
Yes. Suboxone is considered safe for long-term use under medical supervision. It helps stabilize brain chemistry and supports lasting sobriety. We regularly assess patients at our Medication-Assisted Treatment Center in Maryland to ensure safety and comfort.
Can MAT help with alcohol addiction too?
Absolutely. Naltrexone, Acamprosate, and Disulfiram are FDA-approved medications for treating Alcohol Use Disorder. These medications reduce cravings, deter drinking, and support brain recovery.
What’s the difference between Suboxone, Methadone, and Naltrexone?
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Suboxone: Partial opioid agonist—reduces cravings with minimal euphoria
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Methadone: Full opioid agonist—more potent, typically used in long-term, high-dependence cases
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Naltrexone: Opioid antagonist—blocks effects of opioids and alcohol; requires detox before starting
Your treatment team at MD M.A.T.T. will help determine the safest and most effective option based on your history and goals.
Do I need to detox before starting MAT?
Yes, especially for Naltrexone or Vivitrol. For Suboxone, a short period of withdrawal is often required before induction. We guide you through this process safely at our Medication-Assisted Treatment Center in Maryland.
How long will I need to take MAT medications?
There’s no universal timeline. Some patients benefit from MAT for a few months; others for years. At MD M.A.T.T., we personalize your plan and reassess regularly to determine when tapering is appropriate—or when continuation provides stability.
Can I still work or take care of my family while in MAT?
Yes. Our MAT program is outpatient-based and designed to fit into your life. We offer flexible scheduling, telehealth options, and supportive services to help you balance recovery with work, school, or family obligations.
Will I get therapy with MAT at MD M.A.T.T.?
Absolutely. Therapy is a core part of MAT. We offer individual counseling, group therapy, trauma-informed care, and more—all tailored to your recovery journey.
